HP ZBook 150W Thunderbolt 3 Dock Product #: P5Q58AA.I am assuming that installing the Extension pack might be related, but I have not specifically tested it without. So in summary this seems to be an interaction between the ASMedia USB Root Hub driver and the Virtualbox VBoxSVC.exe process. I have observed that Virtualbox (VBoxSVC.exe) does not stop properly on some occasions when closed and need to be killed manually to allow the driver to load. Stopping Virtualbox will allow the driver to load properly and the USB on the docking station will then work again. The driver could not be loaded because a previous version of the driver is still in memory. Windows cannot load the device driver for this hardware because a previous instance of the device driver is still in memory.

This will try to load the ASMedia USB Root Hub driver again but it fails with: This will unload the ASMedia USB Root Hub driver. Start Virtualbox (it is not necessary to actual start any VMs).This will load the ASMedia USB Root Hub driver. Boot the system and attach the docking station.So unloading that driver is a regular occurrence and it is quite disruptive if the USB does not work on that docking station. The problem is that the ASMedia USB Root Hub is part of the devices that loaded and unloaded as part of the docking procedure on the Thunderbolt3 docking station. I can reproduce the same issue and wanted to update that ticket so it is better understood and maybe actually get fixed. I stumbled across the community thread that got opened as response to that ticket.

Dell asmedia root hub driver